Endocrine Abstracts

Introduction: To evaluate if improved thyroid status in patients with hypopituitarism would improve cardiovascular risk markers.Patients and methods: A total of 85 hypopituitary patients (45 women) with GH deficiency; 7 had isolated GH deficiency, 25, 16 and 22 patients had 1, 2 and 3 additional deficits respectively. Fifteen patients had panhypopituitarism. Biochemical and body composition assessment was performed at baseline (when patients were GH na&#...

Aim: to establish a human in vitro system for the study of pituitary cells in culture and subsequently to study the influence of the pro-inflammatory cytokines interleukin (IL)-1β and tumour necrosis factor (TNF)-α on the function of the somatotrophic cells inclusive the ability of the cells to produce IL-6 and IL-8.Methods: Pituitary adenomas were obtained from hypophysectomies of patients with acromegaly. The tissue was enzymatically d...

Objective: Evaluate the influence of altered cortisol binding globulin (CBG) concentration on total cortisol and calculated free cortisol (CFC) during the 250 μg ACTH test.Methods: We included 100 unmedicated healthy individuals (HI) (50M:50F), 13 women taking oral contraception (OC), and 5 men with nefrotic syndrome (NS, prior to glucocorticoid treatment; hypoalbuminaemia <9 g/l; proteinuria >1.6 g/24 h). An ACTH-test was performed between ...

In the thyroid gland the volume of colloid in the follicles varies considerably. The usually used number weighted mean volume (Vn) does not describe this variation in the distribution of the volume of colloid.Aim: To develop a set of assumption-free stereological methods to determine the variation of the volume of colloid in respect of number and size and to determine the coefficient of this variation (CV). For this purpose we introduce the volume-weight...

Background and Aim: Use of anabolic androgenic steroids (AAS) has moved from elite sports to the broader population. Studies suggest that AAS cessation is often associated with immediate various AAS withdrawal and hypogonadal symptoms. Quality of life using a standardized questionnaire has never been assessed in AAS users. The Short-Form 36 (SF-36) questionnaire is a highly validated and used instrument for assessment of quality of life. The questionnaire consists of a total e...

Objective: Growth hormone (GH) activity might be implicated in male reproductive function. One previous study has suggested significantly reduced semen quality in untreated acromegalic patients due to both reduced sperm counts and motility.Design and methods: A retrospective study comprising 10 uncontrolled hypogonadal acromegalic patients (median age 29y) who delivered semen for cryopreservation before initiation of testosterone therapy. Semen ...

Introduction: Gonadotropins from the pituitary gland are essential for testosterone production and spermatogenesis. However, little is known about semen quality in patients with adult onset gonadotropin insufficiency.Aim: To investigate semen quality in men with adult onset hypogonadotropic hypogonadism requiring testosterone replacement therapy.Patients and method: A single center study comprising all hypogonadal men with pituitar...

Somapacitan is a long-acting growth hormone (GH) intended for once-weekly subcutaneous administration. As for GH, the mechanism of action of somapacitan is either directly or indirectly via insulin-like growth factor I (IGF-I). A PK/PD model of somapacitan was developed from the pharmacokinetics (PK) and IGF-I levels from three phase 1 trials data: a single dose/multiple dose trial (0.02–0.24 mg/kg per week) in healthy adults, a multiple dose trial in adults with growth h...

Objective: To determine the effects of long-term growth hormone (GH) treatment on heart anatomy and function among adult GH deficient patients.Design: A retrospective observational study at Copenhagen University Hospital, Rigshospitalet, Denmark between 1999 and 2015.Patients: All patients with available echocardiography data at treatment baseline, 3–5 years and 8–10 years follow up. We included 25 naïve GH deficient...

Hypothesis and aim: Acromegaly is frequently associated with impaired glucose tolerance and diabetes, and concomitant hyperprolactinaemia was suggested to add to this effect. We hypothesized that pituitary prolactin (PRL) histopathology and plasma hyperprolactinaemia has a prognostic value in predicting the risk of glucose metabolic disturbances in acromegalic patients. The aim of this study was to examine glucose metabolic outcomes in acromegalic patients with and without his...